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Best Wildlife Enthusiast Road Trip: Jackson to Yellowstone National Park, WY
Route: U.S. 191 (82 miles plus mileage within the park)

You could consider Yellowstone to be America's version of the Serengeti in Africa. Bison, elk, wolves, moose, bears and dozens of bird species live in America's first national park, making it one of the best places in the United States to view wildlife. While animals are abundant inside the park, you'll likely see some species on the short drive from Jackson to the park's south entrance, and at Grand Teton and Jackson Lake along the way.

Runner-Up: Seward Highway, Alaska